2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)-
4SC-202 (free base)
CAS: 910462-43-0
Molecular Formula: C23H21N5O3S
2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)- - Names and Identifiers
2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)- - Physico-chemical Properties
| Molecular Formula | C23H21N5O3S |
| Molar Mass | 447.51 |
| Density | 1.34±0.1 g/cm3(Predicted) |
| Solubility | DMSO: ≥ 58 mg/mL |
| pKa | 12.60±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In HeLa cells, 4SC-202 induced hyperacetylation of histone H3 with an EC50 of 1.1 μm. 4SC-202 induces G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causes spindle collapse and multiple nucleation centers. In addition, 4SC-202 exhibited broad-spectrum anti-tumor activity against human cancer cell lines with an IC50 of 0.7 μm. |
| In vivo study | In Vivo, 4SC-202 has high oral bioavailability and exhibits high metabolic stability and low plasma clearance. In the A549 NSCLC xenograft and RKO27 colon cancer models, 4SC-202 (120 mg/kg p.o.) showed significant potent antitumor activity. |
2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.235 ml | 11.173 ml | 22.346 ml |
| 5 mM | 0.447 ml | 2.235 ml | 4.469 ml |
| 10 mM | 0.223 ml | 1.117 ml | 2.235 ml |
| 5 mM | 0.045 ml | 0.223 ml | 0.447 ml |
Last Update：2024-01-02 23:10:35
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CAS: 910462-43-0
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Product Name: 4SC-202 (free base) Visit Supplier Webpage Request for quotation
CAS: 910462-43-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 910462-43-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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